This study, lead by PhD student Pratik Samant in TRUE lab, shows that there is no significant temperature rise in our nanoscale photoacoustic tomography (nPAT) for imaging a single living cell. nPAT uses a laser-induced acoustic pulse to generate a nanometer-scale image. The primary motivation behind this imaging technique is the imaging of biological cells in the context of diagnosis without fluorescent tagging. We believe that nPAT will open an avenue for disease diagnosis and cell biology studies at the nanometer-level.
Reference:
Pratik Samant, Jian Chen, Liangzhong Xiang, “Characterization of the temperature rise in a single cell during photoacoustic tomography at the nanoscale,” J. Biomed. Opt. 21(7), 075009 (2016), doi: 10.1117/1.JBO.21.7.075009.